Research Paper Helicobacter Pylori Free Essays

string(194) " This runs the risk of decreased patient compliance, more side effects and a greater cost, but ultimately it boils down to local and national guidelines, which vary from one country to another\." Helicobacter pylori| Previously named Campylobacter pyloridis, is a Gram-negative, microaerophilic bacterium found in the stomach. | | Microbiology (B1325) Research Paper| Detailed Introduction Helicobacter pylori are a species of epsilon proteobacteria which colonizes the harsh environment of the human stomach. Its name refers to both its spiral shape (Helicobacter) and the area of the lower stomach which it habitually colonizes: the gateway (pylorus) between the stomach and small intestine (Meyers, 2007). We will write a custom essay sample on Research Paper Helicobacter Pylori or any similar topic only for you Order Now This bacterium is thought to be present within up to 50% of the human population and has been linked to the development of a number of different medical conditions (Chalmers et al. 2004). This report will provide information about the discovery of H. pylori as well as its morphological characteristics, taxonomic information, biochemical/metabolic characteristics, chemotherapeutic methods of control/treatment/eradication, immunological responses, pathological information, and epidemiology information. Morphological Characteristics Helicobacter pylori are a spiral-shaped, Gram-negative rod approximately 0. x 3. 0 micrometers in size. It is catalase-positive organism which has 4-6 sheathed flagella attached to one pole which allow for motility. It lives in the human stomach and duodenum. H. pylori possess five major outer membrane protein (OMP) families. The largest family includes known and putative adhesions. The other four families include porins, iron transporters, flagellum-associa ted proteins and proteins of unknown function. Like other typical Gram-negative bacteria, the outer membrane of H. pylori consists of phospholipids and lipopolysaccharide (LPS). The O antigen of LPS may be fucosylated and mimic Lewis blood group antigens found on the gastric epithelium. The outer membrane also contains cholesterol glucosides, which are found in few other bacteria. H. pylori has four to six lophotrichous flagella; all gastric and enterohepatic Helicobacter species are highly motile due to flagella. The characteristic sheathed flagella filaments of Helicobacter are composed of two copolymerized flagellants, FlaA and FlaB. [1](From Wikipedia, the free encyclopedia). Taxonomic Information Helicobacter pylori are a gram-negative, spiral-shaped organism associated with gastrointestinal disease in humans. It has a worldwide prevalence, with approximately 50% of the world’s population infected. Before the first isolation and documentation of this organism from the human stomach in 1982, it was assumed that the human stomach was a sterile environment because of the high levels of acid, which would exclude it as an ecologic niche for any organism. This bacterium is the human-adapted Helicobacter primarily found in the gastric mucosa and areas of gastric metaplasia in the duodenum and occasionally in Meckel’s diverticulum and the rectum. It has been cultured rarely from feces, blood, and saliva. It can be detected by polymerase chain reaction (PCR) in dental plaque and feces. In the latter instances, the viability of the bacteria is in question. H. pylori also have been found in nonhuman primates and cats. H. pylori detection in animals is not common and could be due to human contact with animals. To date, no environmental reservoir has been shown. [2](http://www. gastro. theclinics. com/article/S0889-8553(05)70135-7/abstract) Biochemical/Metabolic Characteristics The genus Helicobacter was created in 1989 with H. pylori as the type species. Since then the genus has expanded to include about 18 species. Some species were reclassified from Campylobacter, but most were newly discovered microorganisms from gastric or intestinal sites in mammalian host animals. The essential property of almost all helicobacter is the presence of sheathed flagella. Most species possess strong ureolytic ability, particularly those associated with gastric mucosa, and exhibit considerable diversity in cell morphology with respect to cell length, number and location of flagella, and presence of periplasmic fibrils. H. pylori have a global distribution and infect human gastric mucosa exclusively but there is some evidence for infection in cats. Genomes of isolates from different individuals are unusual in their diversity in gene order and sequences within individual genes. ‘H. heilmannii1 is another gastric spiral shaped organism less frequently infecting humans but commonly found in cat and dog gastric tissue. H. felis is important in the mouse model of infection. A range of conventional phenotypic tests as well as some new PCR based assays are available for identifying isolates of Helicobacter from clinical specimens. [11]( http://bmb. oxfordjournals. org/content/54/1/17. full. pdf) Chemotherapeutic Methods of Control, Treatment, and Eradication Treatment If you are found to have Helicobacter pylori infection, you may wish to have antibiotic treatment of some kind. Treatment of Helicobacter pylori is usually simple ; straight forward. However, occasional patients need repeated endoscopies, biopsies, breath tests and several courses of treatment with different antibiotic combinations. After treatment of H. pylori, it is necessary to repeat one of these tests to see if the germ has been killed or eradicated for good. Only breath tests or endoscopy with biopsy can be used to prove that the bacterium has been eradicated. The blood tests *(serology) is not suitable to monitor H. pylori eradication because antibodies to H. pylori may remain positive for months or even years after successfully killing the H. pylori. [3] (http://www. helico. com/? q=TreatmentForHelicobacterPylori) Eradication Prolonging the treatment period is a possible strategy for improving H. pylori eradication rates. Several studies have been published that tested this approach, including this paper by Calvet et al. These authors studied the value of extending PPI-based triple therapy from 7 to 10 days and found no additional benefit for patients with peptic ulcers. There was, however, a significant benefit for nonulcer dyspepsia patients (an increase from 66% to 77% in the intention-to-treat analysis and from 73% to 91% in the per-protocol analysis). The authors concluded that the treatment period should be extended from 7 to 10 days for patients with nonulcer dyspepsia. As most eradication therapy, however, is given to patients with uninvestigated dyspepsia, it is not unreasonable to argue that longer therapy should be given to all subjects. Distinguishing between patients with ulcer and nonulcer dyspepsia is therefore rather academic and impractical. The most obvious one is that existing PPI-based triple therapy regimens are not perfect. In the community at large, up to 30% of patients might fail this therapy. If clinicians prescribe triple therapy it should therefore be prescribed for longer than 7 days. This runs the risk of decreased patient compliance, more side effects and a greater cost, but ultimately it boils down to local and national guidelines, which vary from one country to another. You read "Research Paper Helicobacter Pylori" in category "Free Research Paper Samples" Alternatively, clinicians might consider some of the newer eradication approaches, such as use of fluoroquinolone-based therapy or sequential treatment. The latter comprises quadruple therapy over a 10-day period, starting with a PPI plus amoxicillin (1,000 mg twice daily) for the first 5 days, followed by PPI plus clarithromycin (500 mg twice daily) and tinidazole (500 mg twice daily) for another 5 days. Intention-to-treat analysis eradication rates of 97%, 92%, and 94% have been reported in children, adults and elderly patients, respectively. Ultimately, clinicians should still strive towards a much simpler eradication strategy, but this will require investment in novel antibiotic discovery or a better understanding of the pathogenesis of H. ylori. Either way, there is much to be gained from continued interest in this little organism. [4](http://www. medscape. com/viewarticle/525100_2) Immunological Responses Lifelong Helicobacter pylori infection and its associated gastric inflammation underlie peptic ulceration and gastric carcinogenesis. The immune and inflammatory responses to H. pylori are doubly responsible: gastric inflammat ion is the main mediator of pathology, and the immune and inflammatory response is ineffective, allowing lifelong bacterial persistence. However, despite inducing gastric inflammation, most infections do not cause disease, and bacterial, host and environmental factors determine individual disease risk. Although H. pylori avoid many innate immune receptors, specific virulence factors (including those encoded on the cag pathogenicity island) stimulate innate immunity to increase gastric inflammation and increase disease risk. An acquired T helper 1 response up regulates local immune effectors. The extent to which environmental factors (including parasite infection), host factors and H. ylori itself influence T-helper differentiation and regulatory T-cell responses remains controversial. Finally, effective vaccines have still not been developed: a better understanding of the immune response to H. pylori may help. [5](http://www. ncbi. nlm. nih. gov/pubmed/17382275) Pathological Information Until the discovery of Helicobacter in 1982, ulcers were thought to be caused by stress. Now it is known that ulcers, in addition to gastritis, are caused by a bacterial infection of H. pylori. Though relatively easy to treat with antibiotics, H. ylori can be a risk factor for gastric cancer if it becomes a long-term infection [6] (Stated by D. J. Kelly, 2004. The University of Sheffield). The body’s natural defenses cannot combat H. pylori because white and killer T cells cannot easily get through the stomach lining. The defense cells eventually die, spilling their superoxide radicals on stomach lining cells, on which H. pylori can feed[6] (Stated by Helicobacter Foundation, 2004). Epidemiology Information The frequency of H pylori infection in the United States may be linked to race. White persons account for 29% of cases, and Hispanic persons account for 60% of cases. Internationally, H pylori are a ubiquitous organism. At least 50% of all people are infected, but an exact determination is not available, mostly because exact data are not available from developing countries. H pylori may be detected in approximately 90% of individuals with peptic ulcer disease; however, less than 15% of infected persons may have this disease. The mortality rate related to H pylori infection is not precisely known, but it seems to be minimal (i. e. , approximately 2-4% of all infected people). Mortality is due to the complications of the infection, uch as gastric ulcer perforation or MALTomas of the GI tract. Otherwise, the morbidity of H pylori infection can be very high. [7](http://emedicine. medscape. com/article/176938-overview#a0199) The pathogenetic role of H pylori may differ depending on geography and race. White persons are infected with H pylori less frequently than persons of other racial groups. The prevalence rate is approximately 20% in white persons, 54% in African American persons, and 60% in Hispanic persons. No sex predilection is known; however, females have a higher incidence of reinfection (5-8%) than males. H pylori infection may be acquired at any age. According to some epidemiologic studies, this infection is acquired most frequently during childhood. Children and females have a higher incidence of reinfection (5-8%) than adult males. [7](http://emedicine. medscape. com/article/176938-overview#a0199) Cultural Characteristics Approximately two-thirds of the world’s population is infected with H. pylori. In the United States, H. pylori are more prevalent among older adults, African Americans, Hispanics, and lower socioeconomic groups. It is not known how H. ylori are transmitted or why some patients become symptomatic while others do not. The bacteria are most likely spread from person to person through fecal-oral or oral-oral routes. Possible environmental reservoirs include contaminated water sources. Iatrogenic spread through contaminated endoscopes has been documented but can be prevented by proper cleaning of equipment. [8](Centers for disease and control prevention) Case St udy 1 Title: Correlation of Helicobacter pylori and gastric carcinoma. Authors: Khanna, AK, Seth, P, Nath, G, Dixit, V K, Kumar, M Issue Date: 26-Jan-2002 Citation: Khanna AK, Seth P, Nath G, Dixit VK, Kumar M. Correlation of Helicobacter pylori and gastric carcinoma. Journal of Postgraduate Medicine. 2002 Jan-Mar; 48(1): 27-8 Language: Eng. Type: Journal Article Abstract: BACKGROUND: Difference of opinion about the prevalence of H. pylori association with gastric cancer exists in the literature. AIMS: To study the correlation of Helicobacter pylori (H. pylori) to gastric carcinoma. METHODS: 50 proved cases of gastric cancer were studied by rapid urease test, culture, histopathology and ELISA test for H. pylori IgG. RESULTS: 68% of cases of gastric cancer were found to be positive for H. pylori infection as compared to 74% of healthy controls. CONCLUSIONS: The prevalence rate of H. pylori infection in our patients of gastric cancer was lower than in the control population though statistically not significant, suggesting that H. pylori may not be responsible for gastric carcinogenesis in this population. Source URI: http://www. jpgmonline. com URI: http://imsear. hellis. org/handle/123456789/116058 MeSH: * Adult * Case-Control Studies * Enzyme-Linked Immunosorbent Assay * Female Helicobacter Infections –complications * Helicobacter pylori –isolation purification * Humans * Male * Middle Aged * Prevalence [9](http://imsear. hellis. org/handle/123456789/116058Stomach Neoplasms –microbiology) Case Study 2 Title: Helicobacter pylori in dental plaque of children and their family members. Authors: Gill, H H, Shankaran, K, Desai, H G Issue Date: 1-Sep-1994 Citation: Gill HH, Shanka ran K, Desai HG. Helicobacter pylori in dental plaque of children and their family members. Journal of the Association of Physicians of India. 1994 Sep; 42(9): 719, 721 Language: Eng. Type: Journal Article Abstract: A prospective study was undertaken to determine the presence of Helicobacter pylori in the dental plaque of children and their family members. 22 children (age range: 2-12 years; males: 16) admitted to the pediatric ward for various disorders and 17 healthy family members (age range: 7-40 years; males: 9) of 13 of these children were screened for presence of Helicobacter pylori in the dental plaque by the rapid urease test. H. pylori were detected in dental plaque of 82% (18/22) children and 88% (15/17) of family members. In 85% (28/33) of the positive cases the rapid urease test was positive within 1 hour. Our observations indicate that Helicobacter pylori are present in the dental plaque of majority of children and their family members. Source URI: http://www. japi. org URI: http://imsear. hellis. org/handle/123456789/95238 MeSH: * Child * Child, Preschool * Dental Plaque –microbiology * Family Health * Female * Helicobacter pylori –isolation purification * Humans * Male * Prospective Studies Appears in Collections: Journal of the Association of Physicians of India [10](http://imsear. ellis. org/handle/123456789/95238) Conclusion The author covered morphological characteristics, taxonomic information, biochemical/metabolic characteristics, chemotherapeutic methods of control/treatment/eradication, immunological responses, pathological information, and epidemiology in this paper. The overwhelming conclusion is that it is critical to survival of the human race that hygiene and education will be the best possible steps to overcome an increasing body of bacteria in our world. References 1. From Wikipedia, the free encyclopedia 2. http://www. gastro. theclinics. om/article/S0889-8553(05)70135-7/abstract) 3. http://www. helico. com/? q=TreatmentForHelicobacterPylori 4. http://www. medscape. com/viewarticle/525100_2 5. http://www. ncbi. nlm. nih. gov/pubmed/17382275 6. Stated by D. J. Kelly, 2004. The University of Sheffield 7. http://emedicine. medscape. com/article/176938-overview#a0199 8. Centers for disease and control prevention 9. http://imsear. hellis. org/handle/123456789/116058Stomach Neoplasms –microbiology 10. http://imsear. hellis. org/handle/123456789/95238 11. http://bmb. oxfordjournals. org/content/54/1/17. full. pdf How to cite Research Paper Helicobacter Pylori, Essays

Richard M. Nixon free essay sample

Richard M. Nixon Early Life Richard Milieus Nixon grew up in Worry, California the son of Quakers Frank and Hannah Nixon. During Onions childhood In Worry, the family was always on the edge of poverty. The lemon grove was unfruitful, and there was little money for anything beyond food and clothing for the growing family. The Nixon never ate in a restaurant or took even a brief vacation. Onions early life was one of boyish stubbornness. He swam in the dangerous Anaheim Canal in spite of repeated warnings from his father, and he insisted upon standing up to ride in the family wagon, although once a fall gave him a serious head injury.He displayed a competitive streak at an early age and would never turn down a challenge or a dare. He also loved to be read to, and after age flee he could read on his own. We will write a custom essay sample on Richard M. Nixon or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page National Geographic was his favorite magazine. Education Nixon graduated form high school in 1930. He possessed extraordinary intelligence and ambition, but his ambitious nature received a serious setback that year. He graduated first in his class and won his high schools Harvard Club award as ;best all-around student. Quote; The award was a scholarship to Harvard university In Cambridge, Massachusetts. In addition, he seemed likely to win a scholarship to Yale university In New Haven, Connecticut. Nixon had dreamed for years of going to a famous college in the East, but his dreams were shattered when he had to turn down both opportunities. Because his older brother Heralds long battle with tuberculoses had drained the familys funds there was no money to pay for the cost of traveling to the East Coast and living there.Nixon swallowed his disappointment and enrolled at nearby Whittler College. Nixon majored In history, and one of his history professors had a profound Influence on his career. This was Dry. Paul Smith, whom Nixon called ;the greatest intellectual inspiration of my early years. ; Smith was a Republican who urged his students to think about the importance of leadership in government. He encouraged them to consider entering public office, and he certainly helped turn Onions thoughts in that direction.In 1934 Nixon graduated from Whittler College after four years on the honor roll. He applied for a scholarship to a new law school, at Duke University In Durham, North Carolina, and asked several of his professors to write to Duke, recommending him for a scholarship. Thanks to one convincing letter from the president of Whittier College saying that Richard Nixon would become a great American leader someday, Nixon was given a scholarship to Duke Law School. After his third year at Duke, Nixon graduated from Duke Law School in 1937.Nixon was ranked third In his class of 25 students. Immediately after graduating, he passed the California Bar Exam which every lawyer wishing to practice law In California must pass. Positions held before the Presidency After passing the bar exam, he practiced law in Whittier, California, and briefly served with the Office of Price Administration before enlisting in the U. S. Navy during World War II. In 1947, Nixon won a seat in the U. S. House of Representatives in a campaign noted for his accusation that his Democratic opponent was supported by Communists.As a member of the House Committee on Un-American Activities, he gained fame for his part In the Alger Hiss spy case. He went on to the U. S. Senate In 1951, again after Nixon became Eisenhower vice-president in 1952 and was unusually visible and active in that role. In 1958, he faced down hostile demonstrations in Peru and Venezuela, and in 1959 he had his famous kitchen debate with Khrushchev at an American exhibit in Moscow. After narrowly losing the presidency to Kennedy in 1960, Nixon lost a bid for governor of California in 1962, a loss which appeared to be the end of his political career.Accomplishments of his Presidency Some of Onions most acclaimed achievements came in his quest for world stability. During visits in 1972 to Beijing and Moscow, he reduced tensions with China and the U. S. S. R. His summit meetings with Russian leader Leonie l. Brethren produced a treaty to limit strategic nuclear weapons. In January 1973, he announced an accord with North Viet Name to end American involvement in Indochina. In 1974, his Secretary of State, Henry Kissing, negotiated disengagement agreements between Israel and its opponents, Egypt and Syria.In his 1972 bid for office, Nixon defeated Democratic candidate George McGovern by one of the widest margins on record. Within a few months, his administration was embattled over the so-called Watergate scandal, stemming from a break-in at the offices of the Democratic National Committee during the 1972 campaign. The break-in was traced to officials of the Committee to Re-elect the President. A number of administration officials resigned; some were later convicted of offenses connected with efforts to cover up the affair.

Black mirror White Bear (Summarization) free essay sample

A woman wakes up with an amnesia, she was in the house where the TV screen showed an unknown symbol. She turns off the TV screen, she caught her attention about the photos of herself and a man with a small girl. She leaves the house and asks for help but people refuse her and continue recording her on their own cellphones. When a masked man leaves his car with his shotgun and ready to shoot the woman, she runs and meets Jem and Damien at the gas store. The man kills Damien, while Jem and the woman escaped the man, Jem explain everything to the woman that it is because of the signal that appearing on the TV screen and mobile screen. Jem said that they are unaffected, but they are also a target of hunters, they planned to reach a transmitter at the white bear to destroy it, while they were escaping the hunters, Baxter offer them a ride. We will write a custom essay sample on Black mirror: White Bear (Summarization) or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page But, while there were at the forest, Baxter tried to kill Jem and the woman, Baxter rang her phone while he was busy talking to someone, Jem walked away and he noticed that Jem escaped. He tried to torture the woman, but Jem came back and killed Baxter. Jem and the woman continue traveling until they reached the transmitter, the two hunters attack and tried to kill them.The woman took the wrestle’s shotgun and shoot it to the hunters, but the shotgun only sprays confetti. The walls open and the crowded people shout, the woman forced to sit in the chair, someone tells everything to her, that her name is Victoria Skillane, and the small girl in the photo was Jemima Sykes, and the man was her fiance name Iain Rannoch. Iain has a tattoo was the symbol that she saw in the TV screen, Iain tortured and killed Jemima before he burned her body, while Victoria remains to stay and recorded Iain’s actions on her mobile phone. Iain committed suicide in his cell. Victoria was undergone in the daily punishment she experienced in the White Bear Justice Park named after Jemima’s white teddy bear. Victoria is driven back to the house while the crowded people remain recording herm and they arranged everything where it started.Black Mirror: White Bear (Reflection)Victoria Skillane was a very popular woman. Nowadays, when we caught an accident or anything that can fulfill someone’s attention, we record it through our mobile phones and upload it. We recorded it, just like Victoria did when Iain tortured and killed Jemima. Victoria just only watched and recorded what was happened. If I were Victoria, I called the police and tell what was happened so that Jemima did not die. There’s no difference between Victoria and those people nowadays because what Victoria did is like what we are doing. If we have caught about something we use our phone to capture and recorded it instead of going or call the police station to prevent the accident. For me, its okay to give a punishment for Victoria to learn what was her done to killed a small girl named Jemima. Victoria and Iain deserve to be punished by many people. She deserves what was her experienced.

Effects of Economics, Race and Class on Social Standing essays

Effects of Economics, Race and Class on Social Standing essays One of the great things about America is that we are supposed to have a class-less society. Some countries have a class structure that is impossible to break. If you are born poor, you will die poor. There is no hope to break the cycle. That should not be the case in America. We like to believe that anyone can find fame and fortune in this country. The promise is that you can work hard and make it big. With this egalitarian outlook, America sounds like a great place to live. The theory is that we are all equal, and have an equal chance of achieving the American Dream. The Dream itself has many definitions, but for my purpose, I am going to assume it means that we can be upwardly mobile concerning social standing. Americans can be born poor and die rich. Of course, there are many subtle levels in between. That is where we will find popular culture. You see, although we have a class-less society, that does not mean we are totally without classes in our country. It really means we are able to transcend those classes and move up or down. We most certainly do have classes amongst ourselves. Primarily, our class is designated by what material possessions we have at this given moment. Not even what we own or how much money we have. It is the perception of affluence, not the accumulation of wealth, which most Americans value. In America, how others perceive you is what determines your social standing. Popular culture is out there for the masses. It is to give the lower and middle class people something to strive for. It tells us that, to be successful, we must drive a car costing more than the average annual salary of most Americans. It tells us what clothes to wear, what music we should listen to or where to live. It is through popular culture that our economy is driven. If it were not for credit and leasing, most Americans would never own a home or have a car to drive. This vici...

Reading Responses and Replies Essay Example | Topics and Well Written Essays - 750 words

Reading Responses and Replies - Essay Example Workforce writing is oriented to complete a job-related task; while college writing enables students to explore their thoughts. No wonder, analysis reports at the workplace are very short since managers do not have time to read long paragraphs. However, academic reports may be lengthy depending on the lecturer instructions on word limit. Writing skills are significant in college, because what one learns in college is eventually used in the professional context to present information. In the professional context, writing is an important way of expressing ideas and information in the form of memo, research reports, presentations, and emails. In response to writing, Gareth highlights important tips that apply to both college and workforce writing. To Purdue University, grammar and vocabulary should be perfect to show intelligence. With this in mind, one is entitled to show the professionalism of the English language in writing, thus enabling one to understand the differences in workforc e writing and college writing. Writing is an important component of effective business practice because, it enables the business person to convey his ideas in various forms such as advertising and marketing to attract his target audience. ... Jae is deep in content since he has outlined how college writing tends to be structured as per professor requirement, whereas professional writing is flexible. I agree with this writer because; college students are instructed to write in various guidelines such as word length, writing styles such as MLA and APA among others. However, professional writers follow guidelines of accomplishing a job-related task that a time may be required to be in short paragraphs for easy reading. Response 2 I have chosen to apply for an administration manager post in the Walt Disney Company, the World’s leader in family entertainment. This company is well-known for the production of motion pictures, television network, and film studios amongst others. To be most appealing to this employer, I intend to present my presentation neatly and professionally. In doing this, I will emphasize on researching about the company and the job applied. I will express my interest for working in Walt Disney Compan y based on my pre-research, and put across how am impressed by the company’s success and growth. I will effectively present knowledge of the post am applying. In doing this, I will demonstrate my passion to work for Walt Disney Company. I will show my trust for this company to be the best place to exploit my skills and experiences for the gain of the company. There are various ways that I will demonstrate the skills I have that the employer is seeking. First, I will list all the requirements of an administrative manager am proficient in such as scheduling, organizing, planning, and supervising. In this case, I will customize the responsibilities as per the job post requirement to win

Linkedln Essay Example | Topics and Well Written Essays - 750 words

Linkedln - Essay Example LinkedIn was officially launched in 2003, with a wide network. The company possesses a diversified business model and generates its revenue from talent and marketing solution along with subscription of premium products. It is a social networking site used by the professionals for their business purposes as well as to increase connectivity with the public and other allied professionals in different fields. The site is used for various marketing reasons by the companies and it provides an opportunity to the members to showcase their talents. It provides a business oriented atmosphere and its objective is to increase connectivity. It is a useful social media for developing marketing strategies to increase connectivity for the professionals (LinkedIn Corporation, 2013). Risk Factors The social media with the advancement of technology is becoming an integral part of business networking. The platform is aggressively used by the businesses for the purpose of marketing along with increasing connectivity. LinkedIn can trigger a wide variety of risks to the organizations such as the risk of information leakage. The risk factors involved can be the leakage of confidential information by the third party which can prove to be a breach. The placement of the advertisements on the site of LinkedIn at times can be tricky which might make the user to download the infected application which causes leakage of personal information. This might lead to the misuse of data and might cause a fraudulent act. The loss of privacy can be a risk for the companies using the platform and their customers as well owing to the fact that a significant extent of personal and corporate information is exchanged through LinkedIn. The risk involved for these sites largely come from the hackers as th ey tend to extract the information and cause legal risk. The platform being open for every user does not provide adequate safety, security on social and legal basis. At the same time, the social networking site is useful for showcasing the prevailing opportunities and talents (Navetta, 2011). Growth History and Reasons for Growth LinkedIn site has shown a growth trend in the past few years. In the year 2003, the site had 4500 members in its network. With the use of the diversified business model, the LinkedIn platform has shown a tremendous growth. It has at present nearly 225 million users in not less than 200 countries. It also has revealed a steady growth as it has 4800 employees worldwide in more than 20 languages. The total revenue amassed by LinkedIn in 2013 has been nearly US$393 Million with the increase in the number of members. Moreover, officials from Fortune 500 companies are their members. LinkedIn uses the data driven strategy to enhance the growth of the site and incr ease its revenue. The data provided through the site to the end users are helping to improve the marketing strategies of the user companies. This strategy is facilitating the business and the members to decide on the marketing strategies along with decision making to increase the performance. This kind of strategy aids in providing accurate and efficient data which in turn facilitates the social networking platform in increasing the subscription and in generation of revenue. LinkedIn makes money by using premium accesses, sales of ad for the products and by providing solution to the corporate clients (LinkedIn Corporation,

The General Crisis In The 17th Century History Essay

The General Crisis In The 17th Century History Essay The period of crisis that happened in Europe in the seventeenth century was one of the toughest in history. After the process of expansion and growth experienced during the fifteenth and sixteenth centuries, Europe found itself in a deep crisis that lasted nearly a century. A crisis that was characterize by various features, foremost the demographic, because after the late Middle Ages the population had increased steadily; until it stops abruptly in the sixteenth century even to recede in many places. Other reasons that were attributed for causing this crisis included hunger, wars, revolts, politics, plagues and climate changes. Eric Hobsbawn argues that on the big picture, it was economic and social forces that created this mid 17th century crisis. On the other hand, Trevor Roper emphasized that the main causes for this crisis were the religious and political conflict. Although both arguments can be valid and were present in this disaster, I believe that the root causes of this cris is were religious and political differences, which ultimately led Europe to have economic and social conflicts as well. One important example of this crisis is the thirty years war. It was a war that took place in central Europe (especially in Germany) between 1618 and 1648, in which the majority of the great European powers intervened. This war would mark the future if the European continent in the centuries to follow  [1]  . The origin of this war goes back to the Peace of Augsburg, which basically stated that the religion of the ruler of the land will be the religion of the people. This resolved the conflicts between the Catholics and the Protestants for a while, but due to the diverse religions practiced in the German states, it did not solve the underlying religious issues definitively. Just by analyzing the phrases above, we automatically get the sense that it was religious conflicts the root cause of this war. This is confirmed by the event that sparked the war, the revolt in Bohemia. In this revolt, member of the predominantly protestant bohemian legislature threw two catholic government o fficials pot the window, as a sign of protest against the religious policies of the newly elected king, the catholic Ferdinand II  [2]  . However, the Catholics defeated the protestants, and this leads us to another example of religion causing the 30 years war; the intervention of the Danish and then the Swedish. This happened because of the fear of these kingdoms that their sovereignty as protestant lands was threatened by the Catholic success in the war, and also because the declarations of the king Frederick V, where he said that all Europe should be back to Catholic. Nevertheless, at this point the Catholics are still winning the war, and this catches the awareness of Cardinal Richelieu, who was the chief minister of King Louis XII of France. From this point on, this religious war becomes political, because even though he was catholic, France decides to join the war and help the Protestants. The reason for this was simple, balance of power; the French felt that Habsburgs hav e gained too much power and they did not want just one great power to control Europe  [3]  . This war is a great example of how religious and political reasons shaped this European crisis, and how these events led to the economic and social problems that a war brings, in order to fund the war with money and men. After all, this war was ended with the Treaty of Westphalia; which ironically ended up being like the treaty of the peace Augsburg that stated that the religion of the prince is the religion of the people. The political effects of this war were very traumatic as well, first it weakened the power of the empire, and the individual territories of the Germany gained more autonomy even than before the war  [4]  . Another problem that rose during this crisis was the war of the three kingdoms. This is another great example to argue that Trevor Roper was correct in explaining the main cause of the crisis. This war happened after England, Ireland and Scotland became united under the power of only one ruler. This was possible because, since Queen Elizabeth of England had no direct heir to her throne, the next in line was James Stuart, the king of Scotland  [5]  . So what types of problems this created? First, James was a firm believer of the divine right monarchy, which basically means that he was placed there by god and does not have to report to anyone else. This belief did not bring many problems to other nations; however, the fact that England had a parliament created a lot of political tensions in this era. Expanding upon this, the wealth that the members of the parliament had acquired from the agricultural innovation, the expansion of their land and sheep count, increased this problems e ven more, because they now wanted to match their political power with their economic power. The fact of this happening brings us back to our thesis, and shows a religious problem becoming political, which ultimately becomes social. I argue this because the parliament starts to have power from the times of King Henry, when he needed their approval to separate from the Catholic Church (religion). Years after, this backfires to King James, because it gave more authority to the wealthy parliament, and clash with his ideals of divine right and absolutism (Politics). Subsequently, creating a lot tension and confusion among the people of the three kingdoms, whose laws and taxes kept changing as the power of the monarchy and the parliament would fluctuate (Social)  [6]  . To further support our point, we can cite the historian Paul Hazard, who coined the term crisis of the European consciousness to define an ideological crisis that could be found in the intellectual ambient of Europe after the wars of religion  [7]  . This is a valid argument since it is logical to believe that religious conflicts could rupture the emotional stability of a society that is very much influenced by god and religion. The raise and growth of new religions that differed in many matters with ancient Catholicism brought into the map many thinkers that challenged even more the traditional beliefs.   Intellectuals such as Descartes, Spinoza, Leibniz, Locke and Newton share a common time, it can even be dated astronomically with the famous Halleys comet of 1680 which allowed Pierre Bayle drafting its Charter, and use this to make fun (in a way) at the Religious superstitions and affirm that knowledge must be constantly proven and updated  [8]  . However, this eventuall y created some social problems, since most of the universities and teaching centers were controlled and had the patronage of the church, being either catholic, like the Jesuits, or protestants. This is another example of how religious conflicts (Trevors argument) happened first and the led to social problems (Hobsbawn argument) Possibly the best example of the religious and political causes of this crisis was the glorious revolution. Going back to the origin of the problem, old King James II was a Catholic that had already irritated the parliament by relaxing the restrictions on the Catholics and allowing them to hold positions in public offices  [9]  . Nevertheless, James was old and next line for the throne was his daughter Mary, a protestant that was married to William of Orange; so the parliament does not really take any action. However, things turn ugly after James II has a son that would mean the continuity of Catholic rule in England, which the parliament would not allow. This caused the glorious revolution, and causes James to escape to France with his son, and William of Orange is invited to be king of England  [10]  . It is interesting to see how the biggest political problem that King James II had was the fact that he was catholic; once again religion. In addition, the fact that the parliament is the one that invites William to be king summarizes the amount of power that he would have, which as we can see, was very limited. He was given many restrictions, such as the obligation to be an Anglican, he was not allowed to have a standing army, he was not allowed to veto a parliament act and there was no arbitrary arrest  [11]  . Based on this, comes a liberal social movement that will support the ideas of the parliament in a way, and moves England even further away from absolutism. A leader of this movement is John Locke. We can see in his Two treatises to the government his idea of the natural right to live, which basically states that we all have a right to liberty and the possession of property. Moreover, if the government does not protect the natural right to live of the people, they can reve l and a demand a ruler who does not violate their rights  [12]  . Trevor and Hobsbawn use the Fronde in France as another example of the general crisis. It begun because of general discontent of the people. His beginnings were based on the economic crisis and increasing the tax burden generated to address the cost of participation of France in the Thirty Years War. Its most direct cause, however, can be found in the means used by the monarchy to raise taxes. With the arrival of the regent the people expected the monarchy to cut rates, but not so: Cardinal Mazarin thought that France could support the war and did not let up the pressure. In addition, the Parliament of Paris tried to limit the power of King Louis XIV and also the nobility felt threatened by the king and wanted more of a voice in the government. All of the causes of the Fronde have political implications to it. Even If it is argued that the raise of the taxes was a social problem, it was a political decision to raise the taxes for war and specially to actually enter the war, with the ideals of balance of power  [13]  . In conclusion, the general crisis was characterized by a series of wars, revolts, decline of population and political and social changes that in many cases could have been avoided if the right precautions would have been taken. However, the fact Europe was undergoing a time political absolutism (at least that is what the rulers intended) and the close relation between church and government, made it impossible to avoid the conflicts. The numerous wars that happened (all for political and religious reasons) aided by plagues and diseases, caused the first decline in the population after the middle ages, therefore creating social and economic problems in the region. This is the reason why I believe that Trevor Roper was right by saying that the root cause of the crisis was political and religious (decisions to go to war, monarchs selected for their religion, etc); which then led to economic and social problem(increase of taxation, price revolution, and decline in population), aggravating even more the situation.